## Abstract Isolated mental retardation is clinically and genetically heterogenous and may be inherited in an autosomal dominant, autosomal recessive, or Xโlinked manner. We report here a linkage analysis in a large family including 15 members, 6 of whom presenting Xโlinked nonโsyndromic mental ret
Localization of the gene for a syndrome of X-linked skeletal dysplasia and mental retardation to Xq27-qter
โ Scribed by S. R. Dlouhy; J. C. Christian; J. L. Haines; P. M. Conneally; M. E. Hodes
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 433 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 i
A large family with non-specific X-linked mental retardation (MRX) was first described in 1991 [Glass et al., 19911, with a suggestion of linkage to Xq26-27. The maximum lod score was 1.60 (0 = 0.10) with the F9 locus. The localisation of this MRX gene has now been established by linkage to microsat
A gene responsible for X-linked mental retardation with macrocephaly and seizures (MRX38) in a family with five affected males in three generations was localized to Xp21.1-p22.13 by linkage analysis. Recombination events placed the gene between DXS1226 distally and DXS1238 proximally, defining an in