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Localization of the CDKN4/p27Kip1gene to human chromosome 12p12.3

✍ Scribed by Emmanuel Martin; Valère Cacheux; Hélène Cavé; Jean Michel Lapierre; Denis Paslier; Bernard Grandchamp

Publisher
Springer
Year
1995
Tongue
English
Weight
774 KB
Volume
96
Category
Article
ISSN
0340-6717

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✦ Synopsis

CDKN4/p27Kip1 is a cyclin-dependent kinase (Cdk) inhibitor implicated in G1 phase arrest, which negatively regulates G1 phase progression in response to TGF beta, and might represent a tumor suppressor gene. We report here the chromosomal assignment of the human CDKN4 gene to chromosome 12p12.3 in close proximity to highly polymorphic microsatellite markers.

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