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Localization of Human X-Linked Genes


Book ID
109684842
Publisher
Nature Publishing Group
Year
1973
Tongue
English
Weight
135 KB
Volume
241
Category
Article
ISSN
0028-0836

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Two genes responsible for X-linked mental retardation have been localised by linkage analysis. MRX30 maps to a 28 cM region flanked by the loci DXS990 (Xq21.3) and DXS424 (Xq24). A significant multipoint lod score of 2.78 was detected between the loci DXSll20 and DXS456. MRX31 maps to a 12 cM region

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For diseases with complex genetic etiology, more than one susceptibility gene may exist in a single chromosomal region. Extending the work of Liang et al. ([2001] Hum. Hered. 51:64-78), we developed a method for simultaneous localization of two susceptibility genes in one region. We derived an expre