Living at Risk: The Sibling’s Perspective of Early-Onset Alzheimer’s Disease
✍ Scribed by Karen E. Wain; Wendy R. Uhlmann; Judith Heidebrink; J. Scott Roberts
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 260 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1059-7700
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The apolipoprotein E (ApoE) genotype is a significant risk factor and modulator of age of onset of Alzheimer's disease (AD). We analyzed the effect of the ApoE genotype in two distinct early-onset familial AD groups: families with a mutation in the presenilin-1 gene (PS-1) on chromosome 14, and fami
We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 313 genot