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๐Ÿ“

Liver Immunology: Principles and Practice

โœ Scribed by Ian R. Mackay MD, FRCP, FRACP, FRCPA, FAA (auth.), M. Eric Gershwin MD, FACP, John M. Vierling MD, FACP, Michael P. Manns MD (eds.)


Publisher
Humana Press
Year
2007
Tongue
English
Leaves
468
Category
Library

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โœฆ Synopsis


Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, allograft rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has various applications in several disciplines of science, and as such is further divided.

Liver Immunology: Principles and Practice covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format. Authors also address the key issues that have arisen in this field in recent years, including physiological roles of hepatocytes, sinusoidal lining cells, activated macrophages (Kupffer cells), cholangiocytes and stellate cells, and their modulation of T cells, natural killer (NK) cells and NKT cells. This volume will become a must-read for clinicians, investigators and students, novice and expert alike.

โœฆ Table of Contents


Front Matter....Pages i-xv
Contemporary Liver Immunology and Immunopathology....Pages 1-11
Front Matter....Pages 13-13
A Short Primer on Fundamental Immunology....Pages 15-24
Role and Function of Liver Sinusoidal Endothelial Cells....Pages 25-39
Innate Immune Mechanisms in the Liver....Pages 41-48
Antigen Processing and Presentation in the Liver....Pages 49-59
Adaptive Immunity in the Liver....Pages 61-70
Hepatic NK, NKT, and T Cells....Pages 71-82
Cytokines in Liver Health and Disease....Pages 83-93
Prevalence and Significance of Autoantibodies in Acute and Chronic Liver Diseases and Hepatocellular Carcinoma....Pages 95-110
The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis....Pages 111-121
Clinical Use of Immunopathology Techniques in Liver Diseases....Pages 123-136
Tumor Immunology....Pages 137-149
Front Matter....Pages 151-151
Innate and Adaptive Immune Responses to Bacterial and Parasite Infections....Pages 153-162
Immune Response to Hepatitis A and E Viruses....Pages 163-177
Role of the Immune Response in Hepatitis B....Pages 179-191
Immune Responses in Acute and Chronic Hepatitis C....Pages 193-208
Immunopathogenesis of Extrahepatic Manifestations in HAV, HBV, and HCV Infections....Pages 209-217
Front Matter....Pages 219-219
Immunogenetics of Autoimmune Liver Disease....Pages 221-233
Primary Biliary Cirrhosis and Autoimmune Cholangitis....Pages 235-247
Sclerosing Cholangitis....Pages 249-261
Front Matter....Pages 219-219
Autoimmune Hepatitis....Pages 263-275
Unique Aspects of Autoimmune Hepatitis in Children....Pages 277-283
Overlap Syndromes of Autoimmune Hepatitis With Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis....Pages 285-291
Animal Models of Autoimmune Liver Diseases....Pages 293-306
Front Matter....Pages 307-307
The Immune Response in the Pathogenesis of Alcoholic Liver Disease....Pages 309-321
Immunomodulation Therapy for Alcoholic Hepatitis....Pages 323-336
Role of Immune Response in Nonalcoholic Fatty Liver Disease....Pages 337-345
Front Matter....Pages 347-347
Mechanisms of Acute Liver Failure....Pages 349-359
Front Matter....Pages 361-361
Immune Mechanisms in Drug-Induced Hepatotoxicity....Pages 363-374
Acute and Chronic Liver Diseases Induced by Drugs or Xenobiotics....Pages 375-388
Front Matter....Pages 389-389
Clinical Use of Immunosuppressive Drugs to Control the Immune Response....Pages 391-407
Hepatic Complications of Hematopoietic Cell Transplantation....Pages 409-421
Acute and Chronic Rejection of the Liver Allograft....Pages 423-431
Immunological Tolerance in Allo- and Xenografts....Pages 433-449
Autoimmune Diseases in Transplanted Livers....Pages 451-457
Immunopathogenesis and Outcomes of Recurrent Hepatitis C....Pages 459-470
Back Matter....Pages 471-486

โœฆ Subjects


Hepatology; Gastroenterology; Internal Medicine; Immunology


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