Clinical Immunology: Principles and Practice

✍ Scribed by Robert Rich, Thomas Fleisher, William Shearer, Harry Schroeder, Anthony Frew, Cornelia Weyand

• Publisher: Elsevier
• Year: 2018
• Tongue: English
• Leaves: 1357
• Edition: 5th Edition
• Category: Library

✦ Synopsis

Keep abreast of the latest advances in this complex field with the 5th Edition of Clinical Immunology: Principles and Practice. This substantially revised edition by Drs. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, and Cornelia M. Weyand, offers authoritative guidance from some of the most respected global leaders in immunology, helping you navigate today’s latest knowledge and evidence-based practices that result in improved patient care. This trusted resource features sweeping content updates, rewritten chapters, a highly clinical perspective, and an easy-to-use organization designed to enhance your diagnosis and management skills in daily practice.

Key Features
User-friendly format features color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.

✦ Table of Contents

Section 1 - Principles of Immune Response View less >

1. The Human Immune Response

2. Organization of the Immune System

3. Innate Immunity

4. Antigen Receptor Genes, Gene Products, and Co-Receptors

5. The Major Histocompatibility Complex

6. Antigens and Antigen Presentation

7. B-Cell Development and Differentiation

8. T-Cell Development

9. Cytokines and Cytokine Receptors

10. Chemokines and Chemokine Receptors

11. Lymphocyte Adhesion and Trafficking

12. T-Cell Activation and Tolerance

13. Regulated Cell Death

14. The Microbiota in Immunity and Inflammation

Section 2 - Host Defense Mechanisms and Inflammation View less >

1. Immunoglobulin Function

2. Helper T-Cell Subsets and Control of the Inflammatory Response

3. Cytotoxic T Lymphocytes and Natural Killer Cells

4. Regulatory Immune Cells

5. Host Defenses in the Skin

6. Host Defenses at Mucosal Surfaces

7. Complement in Host Deficiencies And Diseases

8. Phagocyte Deficiencies

9. Mast Cells, Basophils, and Mastocytosis

10. Eosinophils and Eosinophilia

Section 3 - Host Defenses to Infectious Agents View less >

1. Host Defenses to Viruses

2. Host Defenses to Intracellular Bacteria

3. Host Defenses to Extracellular Bacteria

4. Host Defenses to Spirochetes

5. Host Defenses to Fungi

6. Host Defenses to Protozoa

7. Host Defenses to Helminths

Section 4 - Immunologic Deficiencies View less >

1. Approach to the Evaluation of the Immunodeficient Patient

2. Human Genomics in Immunology

3. Primary Antibody Deficiencies

4. Primary T-cell Immunodeficiencies

5. Immunodeficiencies at the Interface of Innate and Adaptive Immunity

6. Infections in the Immunocompromised Host

7. Immune Deficiencies at the Extremes of Age

8. HIV Infection and Acquired Immunodeficiency Syndrome

9. Autoantibody Mediated Phenocopies of Primary Immunodeficiency Diseases

Section 5 - Allergic Diseases View less >

1. Immunological Mechanisms of Airway Diseases and Pathways to Therapy

2. Urticaria, Angioedema, and Anaphylaxis

3. Allergic Reactions to Stinging and Biting Insects

4. Atopic and Contact Dermatitis

5. Food Allergy

6. Eosinophil-Associated Gastrointestinal Disorders

7. Allergic Disorders of the Eye

8. Drug Hypersensitivity

9. Occupational Respiratory Allergies

Section 6 - Systemic Immune Diseases View less >

1. Mechanisms of Autoimmunity

2. Systemic Lupus Erythematosus

3. Rheumatoid Arthritis

4. Juvenile Idiopathic Arthritis

5. Sjögren’s Syndrome

6. Scleroderma-Systemic Sclerosis

7. Inflammatory Muscle Diseases

8. Spondyloarthritis

9. Small and Medium Vessel Primary Vasculitis

10. Large-Vessel Vasculitides

11. Systemic Autoinflammatory Syndromes

12. Antiphospholipid Syndrome

Section 7 - Organ-Specific Inflammatory Disease View less >

1. Immunohematologic Disorders

2. Bullous Diseases of the Skin and Mucous Membranes

3. Immunology of Psoriasis

4. Myasthenia Gravis

5. Multiple Sclerosis

6. Autoimmune Peripheral Neuropathies

7. Immunologic Renal Diseases

8. Inflammation and Atherothrombosis

9. Autoimmune Thyroid Diseases

10. Diabetes and Related Autoimmune Diseases

11. Immunologic Lung Diseases

12. Sarcoidosis

13. Immunologic Ocular Disease

14. Immunologic Diseases of the Gastrointestinal Tract

15. Inflammatory Hepatobiliary Diseases

Section 8 - Immunology of Neoplasia View less >

1. Tumor Immunotherapy

2. Lymphoid Leukemias

3. Lymphomas

4. Monoclonal Gammopathies

Section 9 - Transplantation View less >

1. Concepts and Challenges in Organ Transplantation: Rejection, Immunosuppression, and Tolerance

2. Immune Reconstitution Therapy for Immunodeficiency

3. Hematopoietic Stem Cell Transplantation for Malignant Diseases

Section 10 - Prevention and Therapy of Immunologic Diseases View less >

1. Immunoglobulin Therapy: Replacement and Immunomodulation

2. Gene Therapy

3. Glucocorticoids

4. Immunomodulating Pharmaceuticals

5. Protein Kinase Antagonists as Therapeutic Agents for Immunological and Inflammatory Disorders

6. Biological Modifiers of Inflammation

7. Vaccines

8. Immunotherapy of Allergic Disease

Section 11 - Diagnostic Immunology View less >

1. Flow Cytometry

2. Assessment of Functional Immune Responses

3. Assessment of Neutrophil Function

4. Assessment of Human Allergic Diseases

5. Molecular Methods

Appendices View less >

1. A1: Selected CD Molecules and their Characteristics

2. A2: Laboratory Reference Values

3. A3: Vaccine Schedules