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Liquid Phase Synthesis of Peptides

✍ Scribed by BAYER, E.; MUTTER, M.

Book ID
109682716
Publisher
Nature Publishing Group
Year
1972
Tongue
English
Weight
194 KB
Volume
237
Category
Article
ISSN
0028-0836

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An expeditious liquid-phase synthesis of
An expeditious liquid-phase synthesis of cyclic peptide nucleic acids
✍ Jeroen C Verheijen; Gijsbert M Grotenbreg; Ludo Hart de Ruyter; Pieter A.M van d πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 129 KB

Suitably protected linear precursors of cyclic PNAs can be readily obtained by BOP/DiPEA coupling of the corresponding sub-monomers. Conversion of the linear PNA dimers into the pentafluorophenyl esters allows cyclization by intramolecular attack of the deprotected primary amino function under dilut