𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Liquid-phase synthesis of a cyclic hexameric peptide nucleic acid

✍ Scribed by Geoffrey Depecker; Caroline Schwergold; Christophe Di Giorgio; Nadia Patino; Roger Condom

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
114 KB
Volume
42
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

An expeditious liquid-phase synthesis of
An expeditious liquid-phase synthesis of cyclic peptide nucleic acids
✍ Jeroen C Verheijen; Gijsbert M Grotenbreg; Ludo Hart de Ruyter; Pieter A.M van d πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 129 KB

Suitably protected linear precursors of cyclic PNAs can be readily obtained by BOP/DiPEA coupling of the corresponding sub-monomers. Conversion of the linear PNA dimers into the pentafluorophenyl esters allows cyclization by intramolecular attack of the deprotected primary amino function under dilut

Solid-Phase synthesis of peptide nucleic
Solid-Phase synthesis of peptide nucleic acids
✍ Dr. Leif Christensen; Richard Fitzpatrick; Brian Gildea; Kenneth H. Petersen; He πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 638 KB

Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected PNA

Solid phase synthesis of protected pepti
Solid phase synthesis of protected peptide nucleic acids
✍ Oliver Seitz πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 234 KB

Boc/'Z-protected PNA oligomers were synthesised on solid phase. The use of the allylic HYCRON resin allowed for the application of both Boc-and Fmoc-protecting groups. Highest yields were obtained when the monomeric building block was synthesised on solid phase rather than loaded as preformed unit.