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Liquid-phase synthesis of mixture-based bicyclic β-lactam libraries

✍ Scribed by Szilvia Gedey; Ferenc Fülöp; Pirjo Vainiotalo; Peter A. M. De Witte; Istvían Zupkó

Publisher
Journal of Heterocyclic Chemistry
Year
2003
Tongue
English
Weight
70 KB
Volume
40
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Five sets of 27‐membered combinatorial libraries of alicyclic β‐lactams were prepared via liquid‐phase Ugi 4‐center 3‐component reactions (U‐4C‐3CR) utilizing 3 different cis β‐amino acids, 3 different isonitriles and 5×3 sets of aldehydes. Through combinations of the building blocks of one of these libraries, all of the possible sublibraries were also generated. A few azetidinone derivatives were synthesized individually by parallel synthesis.

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