✦ LIBER ✦

Liquid chromatography/thermospray mass spectrometry of mustard and its metabolites

✍ Scribed by S. Munavalli; E. M. Jakubowski; H. D. Durst

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 386 KB
Volume: 30
Category: Article
ISSN: 1076-5174
DOI: 10.1002/jms.1190301212

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

There is considerable interest in the detection and analysis of chemical warfare agents. Since thermospray provides soft ionization and interesting fragmentation patterns under discharge conditions, the liquid chromatographic/thermospray mass spectrometric behavior of bis(2‐chloroethyl) sulfide and its metabolites was investigated. All of the metabolites except mustard sulfone and thiodiglycol sulfone indicated the presence of a three‐membered cyclic sulfonium ion intermediate or its equivalent in their mass spectra. Other observed reactions of the above substrates include polymerizations and nucleophilic substitution reactions.

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