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Liquid chromatography/electrospray mass spectrometry of bioactive terpenoids inGinkgo biloba L.

✍ Scribed by Mauri, Pierluigi; Migliazza, Barbara; Pietta, Piergiorgio

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 133 KB
Volume: 34
Category: Article
ISSN: 1076-5174
DOI: 10.1002/(sici)1096-9888(199912)34:12<1361::aid-jms895>3.0.co;2-6

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✦ Synopsis

Standardized extracts of Ginkgo biloba leaves are mainly used in the treatment of peripheral and celebral circulation disorders, and also as a remedy against asthma, coughs, bladder inflammation, blenorrhagia and alcohol abuse. The leaf extracts contain biflavones, flavonol glycosides and terpene lactones. This paper reports a method based on liquid chromatography coupled with electrospray mass spectrometry for the analysis of terpenoids in G. biloba extracts. This method allows the rapid isocratic separation of underivatized ginkgolides (GA, GB, GC and GJ) and bilobalide at very low levels (10 pg on the column) and their quantitative detection by external standardization with relative standard deviations of 3 and 5% for intra-and inter-day analyses, respectively.

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