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Liquid chromatography tandem mass spectrometry method for determination of N-acetylcysteine in human plasma using an isotope-labeled internal standard

✍ Scribed by Chuan Lu; Gangyi Liu; Jingying Jia; Yuzhou Gui; Yanmei Liu; Mengqi Zhang; Yun Liu; Shuijun Li; Chen Yu

Book ID
111698884
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
431 KB
Volume
25
Category
Article
ISSN
0269-3879

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Liquid chromatography tandem mass spectrometry method for determination of bisoprolol in human plasma using d5-bisoprolol as the internal standard
✍ Gang-yi Liu; Wei Wang; Jing-ying Jia; Chuan Lu; Yan-mei Liu; Meng-qi Zhang; Yun 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 569 KB

## Abstract A simple, reliable and sensitive liquid chromatography tandem mass spectrometry (LC‐MS/MS) protocol was developed and validated for quantification of bisoprolol in human plasma. The sample was pretreated with a simple procedure of protein precipitation and an isotope‐labeled d5‐bisoprol