Liquid chromatographic analysis of cimetidine with procainamide as internal standard

✍ Scribed by Michael S. Ching; George W. Mihaly; D. Brian Jones; Richard A. Smallwood

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 131 KB
• Volume: 73
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600730745

✦ Synopsis

Liquid Chromatographic Analysis of Cimetidine with Procainamide as Internal Standard

Keyphrases 0 Cimetidine-HPLC analysis in plasma and urine 0 Liquid chromatography-analysis of cimetidine in plasma and urine

To the Editor:

We recently reported in this journal a simple and sensitive liquid chromatographic assay for cimetidine in plasma and urine (I). Chromatographic separation was performed on a radially compressed column', which allowed much faster and more efficient chromatography than previously described assays (1). However, since burimamide (the internal standard) is no longer manufactured, this has rendered our assay inapplicable by other investigators. We have therefore examined the chromatography of a wide variety of other compounds, including many other Hz-antagonist analogues, and found procainamide to be the most suitable alternative internal standard to burimamide. This results in minimal modification