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Lipoxins A4 and B4 Total Synthesis Including Deprotection Studies

✍ Scribed by Christine Gravier-Pelletier; Jacques Dumas; Yves Le Merrer; Jean-Claude Depezay

Book ID
108372077
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
853 KB
Volume
48
Category
Article
ISSN
0040-4020

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πŸ“œ SIMILAR VOLUMES

Total synthesis of lipoxins A4 and B4 fr
Total synthesis of lipoxins A4 and B4 from d-isoascorbic acid
✍ C. Gravier-Pelletier; J. Dumas; Y. Le Merrer; J.C. Depezay πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 French βš– 292 KB

A total convergent synthesis of lipoxins A4 and B4 has been carried out via four optically pure a-hydroxy and a$-dihydroxyaldehydes, obtained from D-isoascorbic acid as a single starting material. Connection by a six carbons unit uses Wittig-type reactions notably involving a stabilized arsonium yl