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Lipid peroxidation in lung of rat stressed by immobilization: Effects of vitamin E supplementation

✍ Scribed by S. Kovacheva; S. R. Ribarov

Publisher: Springer
Year: 1995
Tongue: English
Weight: 507 KB
Volume: 173
Category: Article
ISSN: 0341-2040
DOI: 10.1007/bf00181877

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✦ Synopsis

This study was carried out to examine the possibility of initiation of lipid peroxidation in the lung of Wistar albino male rats stressed by immobilization. The effects of vitamin E supplementation were also investigated. We found that immobilization of rats with normal pulmonary content of vitamin E caused lipid peroxidation in the lung. Decrease of the lung content of unsaturated fatty acids and vitamin E was also established. The immobilization-induced changes of all of these parameters were significantly inhibited by vitamin E injection (100 mg/kg body weight) for 7 days. A possible sequence of events leading to the initiation of lipid peroxidation and lung cell membrane damage in rats stressed by immobilization is discussed.

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