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Status of lipids, lipid peroxidation, and antioxidant systems with Vitamin C supplementation during aging in rats

✍ Scribed by M. Jayachandran; B. Jayanthi; B. Sundaravadivel; C. Panneerselvam

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
577 KB
Volume
7
Category
Article
ISSN
0955-2863

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✦ Synopsis

Molecular mechanisms responsible for age-dependent deterioration of biochemical functions remain unclear. We determined the effect of ascorbic acid supplementation (20 mg/lOO g body weight/day) in young and aged rats for 15, 30, and 60 days. In the aged animals cholesterol, triglycerides, phospholipids, and lipidperoxidation were considerably high, whereas, antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione, ascorbic acid, and cu-tocopherol were low. Administration of ascorbic acid reverted these age-associated differences to the status comparable to young rats. (5. Nutr. Biochem. 7~270-275, 1996.

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