Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer

✍ Scribed by Ahmed S.K. Almushatat; Dinesh Talwar; Peter A. McArdle; Cathy Williamson; Naveed Sattar; Denis St. J O'Reilly; Mark A. Underwood; Donald C. McMillan

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: French
• Weight: 64 KB
• Volume: 118
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.21451

✦ Synopsis

Abstract

The relationship between lipid soluble antioxidant vitamins, lipid peroxidation, disease stage and the systemic inflammatory response were examined in healthy subjects (n = 14), patients with benign prostate hyperplasia BPH (n = 20), localized (n = 40) and metastatic (n = 38) prostate cancer. Prostate cancer patients had higher concentrations of malondialdehyde (p < 0.05) and lower circulating concentrations of lutein (p < 0.05), lycopene (p < 0.001) and β‐carotene (p < 0.05). Patients with metastatic prostate cancer, when compared with patients having localized disease, had a higher Gleason score (p < 0.01) and had more hormonal treatment, but lower concentrations of PSA (p < 0.05), α‐tocopherol (p ≤ 0.05), retinol (p < 0.01), lutein (p < 0.05) and lycopene (p < 0.01). In the prostate cancer patients, PSA was correlated with the concentrations of the lipid peroxidation product, malondialdehyde (r~s~ = 0.353, p = 0.002). C‐reactive protein was not correlated with the vitamin antioxidants nor malondialdehyde. In contrast, there was a negative correlation between malondialdehyde concentrations and both lutein (r~s~ = −0.263, p = 0.020) and lycopene (r~s~ = −0.269, p = 0.017). These results indicate that lower concentrations of carotenoids, in particular, lycopene reflect disease progression rather than the systemic inflammatory response in patients with prostate cancer. © 2005 Wiley‐Liss, Inc.