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Linkage to Xq28 in a family with nonspecific X-linked mental retardation

✍ Scribed by Ann-Marie Nordström; Maila Penttinen; Harriet Koskull

Publisher
Springer
Year
1992
Tongue
English
Weight
944 KB
Volume
90
Category
Article
ISSN
0340-6717

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✦ Synopsis

Linkage analysis was performed in a family with nonspecific X-linked mental retardation (MRX). Affected individuals had no clinical characteristics other than mental retardation. Linkage was detected to the marker loci DXS477, DXS465, DXS52, DXS15 and F8C with maximum lod scores of 1.70, 1.32, 2.52, 1.70, and 1.09, respectively (theta = 0.0). The results strongly indicate that the gene for mental retardation in the family studied maps close to DXS52.

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