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Linkage mapping of a nonspecific form of X-linked mental retardation (MRX53) in a large Pakistani family

โœ Scribed by Ahmad, Wasim ;Noci, Sara ;ul Haque, Mohammad Faiyaz ;Sarno, Tiziana ;Aridon, Paolo ;Ahmad, M. Maqbool ;Amin-ud-din, Muhammad ;Rafiq, Muhammad Arshad ;ul Haque, Saeed ;De Fusco, Maurizio ;Ballabio, Andrea ;Franco, Brunella ;Casari, Giorgio


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
72 KB
Volume
100
Category
Article
ISSN
0148-7299

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A genetic linkage study was performed on a large four-generation family with variable nonspecific X-linked mental retardation (MRX16), speech abnormalities, and retardation of all milestones. Significant linkage was found in the Xq28 region with loci DXS52, DXS15, BGN, and DXS1108 with maximum LOD s

Mapping to distal Xq28 of nonspecific X-
โœ Russo, S. ;Cogliati, F. ;Cavalleri, F. ;Cassitto, M.G. ;Giglioli, R. ;Toniolo, D ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 281 KB ๐Ÿ‘ 2 views

Families with mentally retarded males found to be negative for FRAXA and FRAXE mutations are useful in understanding the genetic basis of X-linked mental retardation. According to the most recent data (updated to 1999), 69 MRX loci have been mapped and 6 genes cloned. Here we report on a linkage stu

Mapping of a gene for nonspecific X-link
โœ Caspari, Reiner ;Uhlhaas, Siegfried ;Friedl, Waltraut ;Knapp, Michael ;Propping, ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 216 KB ๐Ÿ‘ 1 views

Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 i

Four families (MRX43, MRX44, MRX45, MRX5
โœ Hamel, Ben C.J.; Smits, Arie P.T.; van den Helm, Bellinda; Smeets, Dominique F.C ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 185 KB ๐Ÿ‘ 1 views

Four families are described in which mental retardation segregates in an X-linked fashion. Mental retardation was the only consistent clinical finding in all affected males. The degree of retardation varied from mild to profound both between and within families. Linkage analysis localized the geneti