Severe nonspecific X-linked mental retardation caused by a proximally Xp located gene: Intragenic heterogeneity or a new form of X-linked mental retardation?
β Scribed by Passos-Bueno, Maria Rita ;Byth, Barbara C. ;Rosenberg, Sergio ;Takata, Reinaldo I. ;Bakker, Egbert ;Beggs, Alan H. ;Pavanello, Rita C. ;Vainzof, Mariz ;Davies, Kay E. ;Zatz, Mayana
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 455 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
W e report on a family in which nonsyndromal mild to moderate mental retardation segregates as an X-linked trait (MRX41). T w o point linkage analysis demonstrated linkage between the disorder and marker DXS3 in Xq21.33 with a lod score of 2.56 at 0 = 0.0 and marker DXSllO8 in Xq28 with a lod score
## Linkage analysis was performed on a fourgeneration family with nonspecific mental retardation (MRX59 ). The five affected males, ranging in age from 2 years to 52 years, have a normal facial appearance and mild to severe mental impairment. Four obligate carriers are physically normal and not ret