Linkage and haplotype analysis of familial early-onset Alzheimer disease in Japanese population
β Scribed by Kouzin Kamino; Keiko Nagano; Tomohiro Katsuya; Yumiko Nishiwaki; Masatoshi Takeda; Hirotaka Tanabe; Tsuyoshi Nishimura; Kunio Ii; Kenzo Fujimoto; Ryotaro Tsujimura; Yasuhiro Nonomura; Hiroshi Yoneda; Toshiaki Sakai; Teruo Nakajima; Masaki Imagawa; George M. Martin; Thomas D. Bird; Gerard S. Schellenberg; Tetsuro Miki; Toshio Ogihara
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 759 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1435-232X
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## Abstract The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with earlyβonset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) earlyβonset nonβVG families showing evidence of linkage
Characteristics of familial aggregation of Alzheimer's Disease were studied in 92 families ascertained through a clinically diagnosed proband with an onset below age 60 years. In each family data were systematically collected on the sibships of the proband, of his father, and of his mother. A total