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Linkage and haplotype analysis of familial early-onset Alzheimer disease in Japanese population

✍ Scribed by Kouzin Kamino; Keiko Nagano; Tomohiro Katsuya; Yumiko Nishiwaki; Masatoshi Takeda; Hirotaka Tanabe; Tsuyoshi Nishimura; Kunio Ii; Kenzo Fujimoto; Ryotaro Tsujimura; Yasuhiro Nonomura; Hiroshi Yoneda; Toshiaki Sakai; Teruo Nakajima; Masaki Imagawa; George M. Martin; Thomas D. Bird; Gerard S. Schellenberg; Tetsuro Miki; Toshio Ogihara


Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
759 KB
Volume
40
Category
Article
ISSN
1435-232X

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## Abstract The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage

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Characteristics of familial aggregation of Alzheimer's Disease were studied in 92 families ascertained through a clinically diagnosed proband with an onset below age 60 years. In each family data were systematically collected on the sibships of the proband, of his father, and of his mother. A total