𝔖 Bobbio Scriptorium
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Lincomycin. X. The chemical synthesis of lincomycin

✍ Scribed by Barney J. Magerlein

Book ID
104238886
Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
157 KB
Volume
11
Category
Article
ISSN
0040-4039

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✦ Synopsis

The discovery of the antibiotic lincomycin (I.) was announced in 1962 (l), and disclosure of its structure was made shortly thereafter (2). Since that time a number of reports describing chemical modification of lincomycin have appeared (3). We now present the first chemical synthesis of lincomycin.

Previous reports from these laboratories have described the cleavage of lincomycin to form the amino sugar, methyl a-thiolincosaminide (z) (4) and trans-l-methyl-4-g-propyl-&-proline (5). The recombination of these fragments as well as the synthesis of the amino acid were

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Synthesis of 1,2,3-Triazole Analogues of
Synthesis of 1,2,3-Triazole Analogues of Lincomycin
✍ Marie-Pierre Collin; Sven N. Hobbie; Erik C. Böttger; Andrea Vasella 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 German ⚖ 242 KB

## Abstract In search for new antibiotics we replaced the amide moiety of lincomycin **1** by a 1,2,3‐triazole ring. The 1,2,3‐triazoles **10a**–**10k** were obtained as single regioisomers by ‘click reaction’ of azide **5** with the alkyne **9k**, derived from propyl hygric acid, and the alkyl, ar