Light-mediated regulation of asymmetric reduction of ketones by a cyanobacterium

✍ Scribed by Kaoru Nakamura; Rio Yamanaka

• Book ID: 104359511
• Publisher: Elsevier Science
• Year: 2002
• Tongue: English
• Weight: 880 KB
• Volume: 13
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(02)00683-3

✦ Synopsis

The stereochemical course of the asymmetric reduction of ketones by a photosynthetic microbe is largely regulated by light. Thus, we find that the enantioselectivity of the reduction of a,a-difluoroacetophenone with Synechococcus elongatus PCC 7942 increases as a result of illumination with fluorescent light. Furthermore, DCMU, an inhibitor of photosynthesis, affects the stereoselectivity, and, under illumination decreases the enantioselectivity of the reduction.