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Ligand-independent activation of estrogen receptor function by 3,3′-diindolylmethane in human breast cancer cells

✍ Scribed by Jacques E. Riby; Grace H.F. Chang; Gary L. Firestone; Leonard F. Bjeldanes

Book ID
113992291
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
443 KB
Volume
60
Category
Article
ISSN
0006-2952

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## Abstract Adipositas correlates with an enhanced risk of developing malignant diseases such as breast cancer, endometrial tumor or prostate carcinoma, but the molecular basis for this is not well understood. Potential mechanisms include increased bioavailability of adipocytokines (__e.g.__ leptin