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MDM2 Enhances the Function of Estrogen Receptor α in Human Breast Cancer Cells

✍ Scribed by Shigehira Saji; Naoki Okumura; Hidetaka Eguchi; Shigeru Nakashima; Akio Suzuki; Masakazu Toi; Yoshinori Nozawa; Shigetoyo Saji; Shin-ichi Hayashi

Book ID
115587425
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
97 KB
Volume
281
Category
Article
ISSN
0006-291X

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Withaferin a suppresses estrogen recepto
Withaferin a suppresses estrogen receptor-α expression in human breast cancer cells
✍ Eun-Ryeong Hahm; Joomin Lee; Yi Huang; Shivendra V. Singh 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 768 KB

## Abstract We have shown previously that withaferin A (WA), a promising anticancer constituent of Ayurvedic medicine plant __Withania somnifera__, inhibits growth of MCF‐7 and MDA‐MB‐231 human breast cancer cells in culture and MDA‐MB‐231 xenografts in vivo by causing apoptosis. However, the mecha