The choice of the ligand can provide control of 1,2-vs. 1,4-addition of organolithium species to α,β-unsaturated carbonyl substrates. With (-)-sparteine as ligand highly enantioenriched configurationally stable α-lithio benzylic and allylic amine derivatives in asymmetric Michael additions give prod
✦ LIBER ✦
Ligand Control and Asymmetric Michael Reactions of Enantioenriched Configurationally Stable N- Boc Anilino Benzylic and Allylic Organolithium Species
✍ Scribed by Park, Yong Sun; Weisenburger, Gerald A.; Beak, Peter
- Book ID
- 126230438
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 201 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0002-7863
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Conjugate Addition Reactions of Configurationally Stable Benzylic and Allylic Organolithium Species. -The organolithium species generated from the amines (I) and (IV), BuLi, and (-)-sparteine react with double activated olefins and nitro olefins to provide addition products in good yields with high