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Ligand Binding Analysis for Human α5β1 Integrin: Strategies for Designing New α5β1 Integrin Antagonists

✍ Scribed by Marinelli, Luciana; Meyer, Axel; Heckmann, Dominik; Lavecchia, Antonio; Novellino, Ettore; Kessler, Horst

Book ID: 126219050
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 244 KB
Volume: 48
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm040224i

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## Abstract The inhibition of integrin function is a major challenge in medicinal chemistry. Potent ligands are currently in different stages of clinical trials for the antiangiogenic therapy of cancer and age‐related macula degeneration (AMD). The subtype α5β1 has recently been drawn into the focu