Lifestyle factors and Ki-ras mutations in colon cancer tumors
β Scribed by Martha L. Slattery; Kristin Anderson; Karen Curtin; Khe-Ni Ma; Donna Schaffer; Sandra Edwards; Wade Samowitz
- Book ID
- 114070487
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 61 KB
- Volume
- 483
- Category
- Article
- ISSN
- 0027-5107
No coin nor oath required. For personal study only.
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We read with interest the paper by Morris et al. 1 reporting a higher incidence of Ki-ras oncogene mutations in villous or tubulovillous adenomas removed from cancer-bearing bowel as opposed to cancer-free bowel. Our calculation of the odds ratio for their data is 3β’125. They found the higher percen
A high frequency of point mutations at codon 12 of the Ki-ras gene has previously been reported for rat kidney mesenchymal tumors induced by methylating N-nitroso compounds. In this study, we analyzed renal tumors with divergent histogenesis, i.e., mesenchymal tumors (sarcomas), cortical epithelial