Ki-ras point mutation characteristically occurs frequently in human pancreatic cancer. To clarify the effect of antisense Ki-ras RNA on various pancreatic cancer cell lines, a plasmid expressing an antisense Ki-ras gene fragment (AS-K-ras-LNSX) was transduced into seven human pancreatic cancer cell
✦ LIBER ✦
Transforming growth factor α activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations
✍ Scribed by Thomas Seufferlein*; Johan Van Lint‡; Susanne Liptay§; Guido Adler*; Roland M. Schmid*
- Book ID
- 118522101
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 230 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Spontaneously immortalized human mammary epithelial cells MCF‐IOA were transfected with an activated c‐Ha‐ras oncogene. Transfected cells (MCF‐IOT) acquire a malignant pheno‐type, as already reported. Studies of l‐2′‐deoxyuridine incorporation in cultures given graded doses of hydrocort