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LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro

✍ Scribed by Stephanie Ghislin, Dorian Obino, Sandrine Middendorp, Nicole Boggetto, Catherine Alcaide-Loridan, Frederique Deshayes


Book ID
119897497
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
376 KB
Volume
12
Category
Article
ISSN
1471-2407

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We examined 10 different melanoma cell lines for cellular expression and release of ICAM-I (CD54) and LFA-3 (CD58) and the influence of cytokines, including IFNcx, IFNy and TNFa. Cellular ICAM-I expression and density varies considerably between the melanoma cell lines. While IFNa has no effect on c