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Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells

✍ Scribed by Spinella, Francesca; Caprara, Valentina; Castro, Valeriana; Rosanò, Laura; Cianfrocca, Roberta; Natali, Pier Giorgio; Bagnato, Anna


Book ID
115516057
Publisher
Springer
Year
2012
Tongue
English
Weight
836 KB
Volume
91
Category
Article
ISSN
0946-2716

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## Abstract ## Background and Methods. VEGF proteins and their receptors are involved in tumor vessel neoformation. The third VEGF receptor, VEGFR3 (flt‐4) is important during both blood vessel development and lymphatic vessel formation. Because HNSCC preferentially metastasizes to regional lymph