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Signal transducer and activator of transcription 3–stimulated hypoxia inducible factor-1α mediates estrogen receptor-α–induced mesenchymal stem cell vascular endothelial growth factor production

✍ Scribed by Meijing Wang; Jiangning Tan; Arthur Coffey; John Fehrenbacher; Brent R. Weil; Daniel R. Meldrum

Book ID: 113763191
Publisher: CTSNet
Year: 2009
Tongue: English
Weight: 547 KB
Volume: 138
Category: Article
ISSN: 1097-685X
DOI: 10.1016/j.jtcvs.2009.03.010

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## Abstract Her‐2/__neu__ (__erb__B‐2) oncogene overexpression is associated with increased tumor progression and metastasis. Fatty acid synthase (FAS), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, has been shown to be one of the genes regulated by Her‐2/__neu__