Levodopa-induced dyskinesia and response fluctuations in primates rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
โ Scribed by C.E. Clarke; M.A. Sambrook; I.J. Mitchell; A.R. Crossman
- Book ID
- 118930296
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 383 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-510X
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## Abstract ## Objective The objective of the present study was to investigate the effect of docosahexaenoic acid (DHA), a polyunsaturated fatty acid (omegaโ3), on levodopaโinduced dyskinesias (LIDs) in parkinsonian 1โmethylโ4โphenylโ1,2,3,6โtetrahydropyridine (MPTP)โtreated monkeys. ## Methods
The present study examines the motor responses of 10-to 12-month-old, male C57 mice that were either given intraperitoneal (IP) injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg per day) or vehicle for 10 consecutive days, followed by IP injections of levodopa (200 mg/kg) pl