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Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys

✍ Scribed by Pershia Samadi; Laurent Grégoire; Claude Rouillard; Paul J. Bédard; Thérèse Di Paolo; Daniel Lévesque

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
427 KB
Volume
59
Category
Article
ISSN
0364-5134

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✦ Synopsis

Abstract

Objective

The objective of the present study was to investigate the effect of docosahexaenoic acid (DHA), a polyunsaturated fatty acid (omega‐3), on levodopa‐induced dyskinesias (LIDs) in parkinsonian 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)–treated monkeys.

Methods

We explored the effect of DHA in two paradigms. First, a group of MPTP monkeys was primed with levodopa for several months before introducing DHA. A second group of MPTP monkeys (de novo) was exposed to DHA before levodopa therapy.

Results

DHA administration reduced LIDs in both paradigms without alteration of the anti‐parkinsonian effect of levodopa indicating that DHA can reduce the severity or delay the development of LIDs in a nonhuman primate model of Parkinson's disease.

Interpretation

These results suggest that DHA can reduce the severity or delay the develoment of LIDs in a nonhuman primate model of Parkinson's disease. DHA may represent a new approach to improve the quality of life of Parkinson's disease patients. Ann Neurol 2006;59:282–288

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