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Systemic 1-methyl, 4-phenyl, 1-2-3-6-tetrahydropyridine (MPTP) administration decreases retinal dopamine content in primates

✍ Scribed by M. Felice Ghilardi; Eunyong Chung; Ivan Bodis-Wollner; Mark Dvorzniak; Andrew Glover; Marco Onofrj

Book ID: 118343095
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 445 KB
Volume: 43
Category: Article
ISSN: 0024-3205
DOI: 10.1016/0024-3205(88)90315-3

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP