Levetiracetam protects against kainic acid-induced toxicity
β Scribed by Herbert Marini; Cinzia Costa; Maria Passaniti; Maria Esposito; Giuseppe M Campo; Riccardo Ientile; Elena Bianca Adamo; Rolando Marini; Paolo Calabresi; Domenica Altavilla; Letteria Minutoli; Francesco Pisani; Francesco Squadrito
- Book ID
- 116717161
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 326 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0024-3205
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## Abstract Metallothioneins I and II (MTI/II) are metalβbinding proteins overexpressed in response to brain injury. Recently, we have designed a peptide, termed EmtinB, which is modeled after the Ξ²βdomain of MTβII and mimics the biological effects of MTI/II in vitro. Here, we demonstrate the neuro
In this investigation, 40 mg/kg of the excitatory neurotoxin kainic acid (KA) was subcutaneously administered to CD2-F1 mice. In this mouse strain morphological damage induced by KA in the hippocampus was markedly concentrated in the CA3 pyramidal neurons. Neuronal injury was accompanied by several