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Vigabatrin protects against kainic acid-induced neuronal damage in the rat hippocampus

✍ Scribed by Toivo Halonen; Riitta Miettinen; Ari Toppinen; Jarkko Tuunanen; Tiina Kotti; Paavo J. Riekkinen Sr.

Book ID
116124860
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
570 KB
Volume
195
Category
Article
ISSN
0304-3940

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In this investigation, 40 mg/kg of the excitatory neurotoxin kainic acid (KA) was subcutaneously administered to CD2-F1 mice. In this mouse strain morphological damage induced by KA in the hippocampus was markedly concentrated in the CA3 pyramidal neurons. Neuronal injury was accompanied by several