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Melatonin protects against neuronal damage induced by 3-nitropropionic acid in rat striatum

✍ Scribed by Eunjoo Nam; Seung Min Lee; Seong Eun Koh; Wan Seok Joo; Sungho Maeng; Heh In Im; Yong Sik Kim

Book ID
113500573
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
209 KB
Volume
1046
Category
Article
ISSN
0006-8993

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In this investigation, 40 mg/kg of the excitatory neurotoxin kainic acid (KA) was subcutaneously administered to CD2-F1 mice. In this mouse strain morphological damage induced by KA in the hippocampus was markedly concentrated in the CA3 pyramidal neurons. Neuronal injury was accompanied by several