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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

✍ Scribed by Katsuno, Masahisa; Adachi, Hiroaki; Doyu, Manabu; Minamiyama, Makoto; Sang, Chen; Kobayashi, Yasushi; Inukai, Akira; Sobue, Gen


Book ID
109933261
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
993 KB
Volume
9
Category
Article
ISSN
1078-8956

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## Abstract Expanded polyglutamine tracts cause neurodegeneration through a toxic gain‐of‐function mechanism. Generation of inclusions is a common feature of polyglutamine diseases and other protein misfolding disorders. Inclusion formation is likely to be a defensive response of the cell to the pr