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Polyglutamine tract expansion of the androgen receptor in a motoneuronal model of spinal and bulbar muscular atrophy

✍ Scribed by F. Piccioni; S. Simeoni; I. Andriola; E. Armatura; S. Bassanini; P. Pozzi; A. Poletti


Book ID
117501749
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
155 KB
Volume
56
Category
Article
ISSN
0361-9230

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## Abstract Expanded polyglutamine tracts cause neurodegeneration through a toxic gain‐of‐function mechanism. Generation of inclusions is a common feature of polyglutamine diseases and other protein misfolding disorders. Inclusion formation is likely to be a defensive response of the cell to the pr