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Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

✍ Scribed by Foust, Kevin D; Wang, Xueyong; McGovern, Vicki L; Braun, Lyndsey; Bevan, Adam K; Haidet, Amanda M; Le, Thanh T; Morales, Pablo R; Rich, Mark M; Burghes, Arthur H M


Book ID
109900707
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
971 KB
Volume
28
Category
Article
ISSN
1087-0156

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Neurodevelopmental consequences of Smn d
✍ Hong Liu; Dina Shafey; Justin N. Moores; Rashmi Kothary πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 776 KB

## Abstract Deletions or mutations in __survival of motor neuron 1__ (__SMN1__) cause motor neuron loss and spinal muscular atrophy (SMA), a neuromuscular disorder, with the most severe type manifesting in utero. Whether SMA is a disease of defects in neurodevelopment and/or neuromaintenance remain