Leukocyte 8-hydroxydeoxyguanosine and aromatic DNA adduct in coke-oven workers with polycyclic aromatic hydrocarbon exposure
โ Scribed by J. Zhang; M. Ichiba; T. Hanaoka; G. Pan; Y. Yamano; K. Hara; K. Takahashi; K. Tomokuni
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 259 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0340-0131
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๐ SIMILAR VOLUMES
## Background: We investigated if blood cu++/zn++ superoxide dismutase, glutathione peroxidase, and catalase activities are increased and total plasma antioxidant concentration is decreased in coke oven workers exposed to polycyclic aromatic hydrocarbons. ## Methods: Ninety-six coke oven workers
Markers of exposure to polycyclic aromatic hydrocarbons (urinary I -hydroxypyrene-glucuronide) and aromatic arnines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 nonsmokers. DNA adducts were determined by P32-postlabeling in the exf