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Lethal Mutagenesis: Targeting the Mutator Phenotype in Cancer

โœ Scribed by Edward J. Fox; Lawrence A. Loeb

Book ID
113900482
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
331 KB
Volume
20
Category
Article
ISSN
1044-579X

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## Abstract Normal human cells replicate their DNA with exceptional accuracy. During every division cycle, each daughter cell receives a full and accurate complement of genetic information. It has been estimated that approximately one error occurs during DNA replication for each 10^9^ to 10^10^ nuc