Leptin induces production of eicosanoids and proinflammatory cytokines in human synovial fibroblasts
β Scribed by LJ Crofford, HH Mehta, BJ Roessler, P Mancuso
- Book ID
- 120707228
- Publisher
- BioMed Central
- Year
- 2004
- Tongue
- English
- Weight
- 391 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1478-6354
- DOI
- 10.1186/ar1400
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H3C 317 i P -A 5 ), and )omt Dr5eascs Ldboratory, Shrrners Hosprtal, MontrGal H3C; IA6 (f t C ), Quebec, Candda In response to interleukin 1 or tumor necrosis factor, human synovial cells and fibroblasts expressed several genes encoding known chemotactic factors or related proteins. Transcripts for
Leptin upregulates collagen expression in hepatic stellate cells (HSCs), but the possible modulation of other actions has not been elucidated. The aim of this study was to investigate the expression and function of leptin receptors (ObR) in human HSCs and the biological actions regulated by leptin.