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Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma—Report of an unusual case

✍ Scribed by Hans-Ullrich Völker; Andreas Zettl; Eugenia Haralambieva; Bernd Blume; Rudolf Hagen; Hans-Konrad Müller-Hermelink; Matthias Scheich

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
593 KB
Volume
32
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

The authors report on leiomyosarcoma after previously treated squamous cell carcinoma (SCC) at the glottis.

Methods.

Primary tumor and relapses were investigated morphologically, immunohistochemically, and with molecular methods.

Results.

The SCC was typical, but few cells showed a spindle‐shaped pattern. The relapse tumor was a spindle‐shaped and epitheloid tumor with the morphological and immunohistochemical appearance of leiomyosarcoma (sm‐actin+, desmin+, caldesmon+, vimentin+, keratin−).

The comparative genomic hybridization (CGH) revealed some gains and losses in the leiomyosarcoma. Because of altered material, the investigation failed in the primary. A fluorescence in situ hybridization (5p) focally detected 3 chromosmomal copies, corresponding to gains on 5p in CGH of leiomyosarcoma.

Conclusion.

Leiomyosarcoma after SCC is very uncommon. A connection between both seems likely in this case. Transdifferentiation, also seen in other tumors or carcinosarcomas, could be based on aberrant differentiation of a pluripotent stem cell. © 2009 Wiley Periodicals, Inc. Head Neck, 2010

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