Diffuse pagetoid squamous cell carcinoma in situ of the esophagus : A case report

✍ Scribed by Peiguo Chu; John Stagias; A. Brian West; Morris Traube

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 518 KB
• Volume: 79
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19970515)79:10<1865::aid-cncr4>3.0.co;2-f

✦ Synopsis

Medicine (Digestive markers of Paget's cells, p53 mutation, and proliferation. Diseases), Yale University, New Haven, Con-RESULTS. The lesion involved 45 cm 2 of mucosa. Large, atypical cells with frequent necticut. mitoses occupied the basal layers of the squamous epithelium and were often separated from more superficial maturing cells by acantholysis. Pagetoid spread of tumor cells into nonneoplastic surface and gland duct epithelium was prominent. The tumor cells expressed cytokeratins of low molecular weight, p53 gene product, and proliferating cell nuclear antigen (PCNA), but lacked markers usually seen in Paget's cells in the breast or vulva. No invasion was evident.

CONCLUSIONS. This extensive in situ squamous cell carcinoma of the esophagus resulted from pagetoid spread of tumor cells. These cells had a phenotype suggestive of origin from primitive epidermal stem cells and also had overexpressed p53 and PCNA, but they lacked the capacity to penetrate the basement membrane. Flat, erythematous areas of esophageal mucosa seen during endoscopy could represent early squamous cell carcinoma and should be biopsied. Cancer 1997;79:1865-70.