✦ LIBER ✦

Lectin-resistant variants of mouse melanoma cells. II. In vitro characteristics

✍ Scribed by Tien-Wen Tao; Jennifer M. Jenkins; Klaus Vosbeck; Alex Matter; Marcia Miller; Brigitte M. Jockusch; Zhong-Hou Shen; Max M. Burger

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 938 KB
Volume: 31
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910310218

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✦ Synopsis

Abstract

Lectin‐resistant variants of B‐16 melanoma cells were selected with wheat‐germ agglutinin, ricin and concanavalin A. They exhibited altered metastasizing capacity and tumorigenicity in C57BL mice. Several in vitro properties were defined and compared including homotypic adhesiveness, microfilament organization, melanin release, activity of tyrosine hydroxylase, DNA content, and karyotypes. The possible relevance of these properties in vitro for the malignant behavior displayed in vivo is discussed. The usefulness of this approach of selecting surface variants to study the problem of metastasis is also discussed.

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