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Leber's hereditary optic neuropathy mutations in ethambutol-induced optic neuropathy

✍ Scribed by Jeong-Min Hwang; Jiyeon Kim; Sung Sup Park


Publisher
Springer
Year
2003
Tongue
English
Weight
179 KB
Volume
250
Category
Article
ISSN
0340-5354

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This article reviews the literature on point mutation of mitochondria1 DNA (mtDNA) among Japanese and the authors' research data on pupil reaction in patients with Leber's hereditary optic neuropathy (LHON). Among Japanese, a higher frequency (80-90%) of point mutation at nucleotide position 11778 o

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## Abstract Pattern‐reversal visual evoked potentials (VEPs) were measured serially in two brothers with Leber's hereditary optic neuropathy during the active phase of the disease. VEP latency and configuration were normal prior to the onset of visual symptoms. The earliest abnormalities consisted