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LC/MS-based non-targeted metabolomics for the investigation of general toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice

✍ Scribed by Shuhai Lin; Zhu Yang; Yang Shen; Zongwei Cai

Book ID: 108146694
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 707 KB
Volume: 301
Category: Article
ISSN: 1387-3806
DOI: 10.1016/j.ijms.2010.06.012

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A dose-dependent reduction of hepatic pyruvate carboxylase levels and activity occurs in C57BL/6J male mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) i.p. in a corn oil carrier. The dose range was from 1 to 75 pg/kg body weight and the analysis was done 8 days postinjection. At the maximum TC