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Dose-response relationship of cytochrome P4501b1 mRNA induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin in livers of C57BL/6J and DBA/2J mice

✍ Scribed by J. Abel; Wei Li; Olaf Döhr; Christoph Vogel; Susanne Donat

Publisher
Springer-Verlag
Year
1996
Tongue
English
Weight
273 KB
Volume
70
Category
Article
ISSN
0340-5761

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✍ Sparrow, Barney R. ;Thompson, Cynthia S. ;Ryu, Byung-Woo ;Selevonchick, Daniel P 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 765 KB

A dose-dependent reduction of hepatic pyruvate carboxylase levels and activity occurs in C57BL/6J male mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) i.p. in a corn oil carrier. The dose range was from 1 to 75 pg/kg body weight and the analysis was done 8 days postinjection. At the maximum TC